LIFE SCIENCE

The Life Science product portfolio consists of products and tools for biological and chemical research aimed at identifying causes of diseases, enabling new drug development, advancing clinical research and developing new industrial products and production processes. These products and tools encompass solutions in research automation, flow cytometry, centrifugation, cellular analysis, genomics, mass spectrometry, liquid chromatography technologies and particle characterization.

 
Flow cytometry is a laser-based technology in which cells suspended in a fluid, flow one at a time through a focus of exciting light, which is scattered in patterns characteristic to the cells and their components. They are often labeled with fluorescent markers so that light is first absorbed and then emitted at altered frequencies. A sensor detecting the scattered or emitted light measures the size and molecular characteristics of individual cells. Tens of thousands of cells can be examined per minute and the data gathered are processed by computer.

Flow cytometry is used in numerous applications in basic research, clinical research, drug discovery and clinical diagnostics testing. Flow cytometers rapidly identify, categorize and characterize multiple types of cells in suspension. Flow cytometers allow analysis of cell types including cell characteristics such as phenotype or functionality, thereby allowing researchers to analyze specific cell populations. This analysis can be performed beyond blood to include bone marrow, tumors and other cells.

Through our partnership with Beckman Coulter, Leriva’s Life Science business unit offers an extensive range of flow cytometers, cell sorters, cell preparation systems, software and reagents and monoclonal antibodies.

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Centrifuges are used in chemistry, biology, biochemistry and clinical diagnostics to isolate and separate the various components of liquids. They are used both in research and clinical settings and operate using the sedimentation principle where the centrifugal acceleration causes denser substances and particles to move outward in the radial direction. While this happens, particles that are less dense are displaced and move to the center. In laboratory centrifuges that uses sample tubes, the radial acceleration causes denser particles to settle at the bottom of the tube while low-density substances rise to the top.

Since 1947 Beckman Coulter has been providing centrifugation solutions for laboratories, hospitals and universities around the world. The Beckman Coulter centrifuge portfolio encompasses both high-performance benchtop models and floor-model. An extensive line of centrifuge rotors is also available for a multitude of specific application areas and are designed to accommodate a variety of sample volumes, g-forces and RPMs.

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At the most basic level, a particle is a discrete sub-portion of a substance. Particle characterization is the process of identifying various particles by shape, size, surface properties, charge properties, mechanical properties and microstructure.

Covering the entire spectrum of particle characterization needs, the Beckman Coulter instruments use techniques that include the Coulter principle, laser diffraction, light scattering and polarized intensity differential scattering (PIDS) to provide the data required for specific application(s).

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Liquid handlers are used to dispense a selected quantity of reagent, sample or other liquid to a designated container.

Beckman Coulter’s Biomek liquid handlers accelerate reliable results that drive discovery. The Biomek Automated Workstations vary in size, deck capacity and overall capabilities. A variety of configurations facilitates performance optimization and reduces hands-on time for most genomic, drug discovery and basic research application workflows. A library of demonstrated next-generation sequencing and nucleic acid sample prep methods, automated across the Biomek portfolio, is also offered.

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Capillary electrophoresis is an analytical technique that separates ions based on their electrophoretic mobility with the use of an applied voltage. The electrophoretic mobility is dependent upon the charge of the molecule, the viscosity, and the atom's radius. The rate at which the particle moves is directly proportional to the applied electric field; the greater the field strength, the faster the mobility.

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